Tuesday, April 22, 2014

Historical Contribution: 1919, HH Young, Mercurochrome

1919

Young HH, White EC, Swartz EO. A New Germicide for the Use in the Genitourinary Tract: "Mercurochrome-220". JAMA. 1919;73:20:1483-91.


At the turn of the 20th Century, one of the urologists biggest tasks was the treatment of urinary tract  and sexually transmitted infections; and their sequelae (including abscess, strictures, etc.).  Hugh Hampton Young and other urologists were in search of a sufficient urinary antiseptic, especially after World War I where venereal disease accounted for an estimated 7 million person-days lost and 10,000 discharges in the US army; and 416,891 hospital admissions among British troops accounting nearly 5% of the entire British force.[1]

mercurochrome-220
In 1919, HH Young reported results from Johns Hopkins in the Journal of the American Medical Association (JAMA), where mercurochrome-220 was used to sterilize the bladder.  Dr. Young wrote:
"The speed with which some old infections of the bladder and kidney pelvis have disappeared after its use is striking, and the absence of irritating and toxic qualities, together with the ability of the patient to retain a 1 per cent, solution for hours without discomfort, are sufficiently proved to establish the possibilities of the drug in these conditions." 
This work earned Young and colleagues a grant from the Interdepartmental Social Hygiene Board.

Young detailed the important properties needed for a new "urinary germicide":

  1. ready penetration of the tissues in which the infection exists
  2. lack of irritation of the drug to tissues
  3. high germicidal activity
  4. ready solubility in water and stability of the solution
  5. freedom from precipitation in urine
  6. sufficiently low toxicity to avoid systemic effects from the small amount of the drug that may be absorbed. 

Young and colleagues then demonstrated the ability of mercurochrome to kill a variety of bacteria including Balantidium Coli and Staphylococcus aureus; and compared its efficacy to other, known antimicrobial compounds.

In Dr. Young's typical meticulous fashion, the authors report the outcomes of 10 patients treated for cystitis, 14 treated topically for chancroid and comment on the outcomes of 51 patients treated for gonorrheal urethritis - all of which responded to treatment.

Read the entire manuscript using the link above or here.


HISTORICAL CONTRIBUTIONS highlight the greatest academic manuscripts from the Brady Urological Institute over the past 100 years.  As the Brady Urological Institute approaches its centennial, we will present a HISTORICAL CONTRIBUTION from each of the past 100 years.  In the most recent experience, the most highly cited article from each year is selected; older manuscripts were selected based on their perceived impact on the field.  We hope you enjoy! 


[1] Mitchell, T.J, & Smith, G.M. (1931) Medical Services: Casualties and Medical Statistics of the Great War, History of the Great War, Based on Official Documents (London: HMSO).

1 comment:

  1. Here priestEka we are here to make your dream of pregnancy and other related human diseases over in your life have a happy home. Wespecialise in helping people with their problems such as.
    1 bringing back your lost .
    2 spell to improve your businesses.
    3 spell to bring back your ex-lover( bring back your husband/wife/boyfriend/girlfriend)
    4 spell for business protection from colleague.
    5 spell to prevent witchcraft from your life and that of your family.
    6 spell to prevent you from accident during your business journey.
    7. spell to get employment easily
    We also specialise in providing solutions in any of this spiritual gynaecology diseases affect human existence such as:
    1 fibroid, asthma, ALL STD,
    2 weakness of man organ
    3 infections of all kind (yeast infection)
    4 blockage from the fallopian tube
    5 cyst. From the ovaries
    6 unpleasant smell from the virgina
    7 irregular menstration, menopause
    8 infertility for easy Conception.
    9.skin diseases, Toilet infection and bad body odor…….Etc..
    10.Watering sperm (low sperm count) not able to get woman pregnant.
    Simply contact the spiritualist PriestEka on (dreka14demons@gmail.com) to get his Herbal Medication to cure your disease and put yourself on a motherhood side of life..
    (No more adoption, with PriestEka your problem will solve and you will have your child with ease.
    Contact us at (dreka14demons@gmail.com) your solution home!

    ReplyDelete