Monday, May 5, 2014

Faculty Spotlight: Arthur Burnett, Restoring Sexual Function

Arthur L. Burnett, II, MD, MBA
Patrick C. Walsh Distinguished Professor of Urology
Director, Basic Science Laboratory in Neurourology
Director, Sexual Medicine Fellowship Program
Faculty Member, Cellular and Molecular Medicine
Graduate Training Program
Arthur L. Burnett, II, MD, MBA, surgeon and neurourologist, is a pioneer in the area of sexual medicine.  Many of his patients are men with prostate cancer who are worried about impotence after radical prostatectomy.  But other men of all ages come to see Burnett for help with issues ranging from ejaculatory disturbances, to libidinal problems, and may need treatment ranging from pharmacotherapy, to injection therapy, to prosthetics, to genital reconstruction following injury or cancer.

Protecting Nerves: Burnett's discovery with Johns Hopkins neuroscientist Solomon Snyder that nitric oxide plays a crucial role in erection led to development of the drug Viagra for erectile dysfunction.[1]  For nearly three decades, much of his lab and clinical work has focused on protecting the integrity of the neurovascular bundles responsibile for erection, easily damaged even in the "nerve-sparing" radical prostatectomy developed by Johns Hopkins urologist Patrick Walsh, MD.  "It may even be from traction, or even that the adjacent dissection somehow exposes the nerves to injury," Burnett says, "Something causes them to sustain an inflammatory setback."

In groundbreaking studies of rats with nerve injury and erectile dysfunction similar to that found in men after radical prostatectomy, he has tested many inflammation-fighting agents and growth factors designed to "preserve, nourish, regenerate and restore nerves to normal function."  One of these is an agent used to combat anemia, erythropoeitin (EPO).  Burnett previously led studies investigating the effects of EPO on erectile function recovery in a rat model of cavernous nerve injury;[2] and now he is investigating those promising results in humans.  In a randomized, controlled clinical trial, still actively enrolling patients, Burnett is studying EPO's ability to enhance nerve function.  EPO is injected the day before, the day of, and the day after radical prostatectomy.

In other work, Burnett has targeted the fragile network of blood vessels and chambers within the penis.  Even though they're not directly traumatized by surgery, "these structures may degenerate or shrivel," he says, "and thus contribute to poor recovery of erectile function in some men after surgery."  To fight this, Burnett is testing such blood vessel-strengthening agents as angiotensin II type 1 receptor antagonists.  In another clinical trial, he is testing an external vibration nerve-stimulatory device, which he helped develop, that may be applied under a specific protocol after surgery.

If you, a loved one, or a patient is interested in one of Dr. Burnett's trials, please call the Urology Clinic at the Brady Urological Institute (410) 955-6100 for an appointment with Dr. Burnett.

Help for incontinence and impotence: Having both urinary incontinence and impotence after radical prostatectomy should be a rare complication, but some men find themselves in this situation and need help.  For the last 13 years, Burnett has offered a successful operation that restores urinary continence and potency at the same time --- implantation of an inflatable penile prosthesis and an artificial urinary sphincter.  "It provides efficient and rapid resumption of both functional disorders, " he says.

Burnett is also conducting further research into utilization and prediction modeling for penile prosthesis surgery.  Dr. Burnett explains,
"Our goal is to approach everything we do thoughtfully and rigorously, so that we can make advances based on what is scientifically meaningful."

This blog entry is extracted from the "Johns Hopkins Urology: News for Physicians from Johns Hopkins Medicine," Spring 2014.




[1] Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH.  Nitric oxide: a physiologic mediator of penile erection.  Science. 1992 Jul 17;257(5068):401-3.
[2] Allaf ME, Hoke A, Burnett AL.Erythropoietin promotes the recovery of erectile function following cavernous nerve injury.J Urol. 2005 Nov;174(5):2060-4.

10 comments:

  1. I just want to share this personal story about how my husband survived the problem of NO ERECTIONS after prostate surgery.
    My husband undertook prostate surgery 3 years ago and before then i always looked forward to great sex with him and after the surgery he was unable to achieve any erections, we were bothered and we tried so many drugs, injections and pumps and rings but none could give him an erection to even penetrate. I searched for a cure and got to know about Dr. Hillary who is renowned for curing problems of this nature and he did encouraged me not to give up and he recommended his herbal medication which my hubby took for 3 weeks and today his sexual performance is optimum. You too can contact him for similar problems on hillaconn@gmail.com. A man who cannot satisfy his wife's sexual need is not a real man!

    ReplyDelete
    Replies
    1. In 2016, I was diagnosed of genital herpes.. I was 31 years old and I had no idea what that was. When my doctor explained to me what Genital Herpes was all about and what type I had...I was freaked out! if I had missed coming to the ER any sooner, I would have possibly died without having the slightest clue of what led to my death, as i have never heard of, or experienced the virus before! The rashes grew and i have been living with it ever since then. Most of the time, I feel dirty knowing i was living with herpes. Though the doctor already encouraged me to keep using my medications even though there is no permanent cure for the virus. So i continued with my medications, which only makes the rashes to disappear, and reappear after some days. Late last year, I started surfing the web, seeking for herbal treatment as alternative. So i was on YouTube one evening,i stumbled upon a comment about Dr. CHUKWU MADU HERBAL HOME and how his herbal medications cured a woman's son of Herpes and I decided to reach out to him. He asked me some questions which i answered, after which He prepared some herbs and sent them to me. He then guided me on how to use them. i used the herbal medications for about ,21days. The rashes gradually dried up. So i went for a test and came back home Herpes free. So My experience with this virus made me to realize, people should find out more about themselves before it's too late. So that when tested positive, they will quickly start making use of the right medication becacause i believe when the right medication is applied, then the sickness is conquered! If you are having any sickness or virus and needs deliverance contact DR.CHUKWU MADU HERBAL HOME. (for your permanent healing) He is the right person to tell your health challenges to. You can contact the doctor via his email address :[ dr.chukwumaduherbalhome@gmail.com ]. Reach him via WhatsApp +2347030936239. Doc. CHUKWU MADU , your saved my life.

      Delete
  2. I just want to share this personal story about how my husband survived the problem of NO ERECTIONS after prostate surgery.
    My husband undertook prostate surgery 3 years ago and before then i always looked forward to great sex with him and after the surgery he was unable to achieve any erections, we were bothered and we tried so many drugs, injections and pumps and rings but none could give him an erection to even penetrate. I searched for a cure and got to know about Dr. Hillary who is renowned for curing problems of this nature and he did encouraged me not to give up and he recommended his herbal medication which my hubby took for 3 weeks and today his sexual performance is optimum. You too can contact him for similar problems on hillaconn@gmail.com. A man who cannot satisfy his wife's sexual need is not a real man!

    ReplyDelete
  3. Here priestEka we are here to make your dream of pregnancy and other related human diseases over in your life have a happy home. Wespecialise in helping people with their problems such as.
    1 bringing back your lost .
    2 spell to improve your businesses.
    3 spell to bring back your ex-lover( bring back your husband/wife/boyfriend/girlfriend)
    4 spell for business protection from colleague.
    5 spell to prevent witchcraft from your life and that of your family.
    6 spell to prevent you from accident during your business journey.
    7. spell to get employment easily
    We also specialise in providing solutions in any of this spiritual gynaecology diseases affect human existence such as:
    1 fibroid, asthma, ALL STD,
    2 weakness of man organ
    3 infections of all kind (yeast infection)
    4 blockage from the fallopian tube
    5 cyst. From the ovaries
    6 unpleasant smell from the virgina
    7 irregular menstration, menopause
    8 infertility for easy Conception.
    9.skin diseases, Toilet infection and bad body odor…….Etc..
    10.Watering sperm (low sperm count) not able to get woman pregnant.
    Simply contact the spiritualist PriestEka on (dreka14demons@gmail.com) to get his Herbal Medication to cure your disease and put yourself on a motherhood side of life..
    (No more adoption, with PriestEka your problem will solve and you will have your child with ease.
    Contact us at (dreka14demons@gmail.com) your solution home!

    ReplyDelete
  4. HOW DR AZIBA HELPED ME ENLARGE MY PENIS SIZE FROM 3.5 INCHES TO 11INCHES LONG AND 8.0 GROWTH
    I got married 2 years ago and it just seemed that there was no excitement in my sex life. My dysfunction to perform to the best of my abilities in bed made it harder for my wife and me to have a good time during sex. And i was having the feelings that she may decide to get a divorce one day. I knew something had to be done in order to improve my sex life and to save my marriage because my marriage was already falling apart, so when i was on my Facebook page i came across a story of how Dr Aziba helped him enlarged his penis to 8ins better.so i Immediately copied the Email address of the Dr and explained to him my problem,he gave me some simply instruction which i must follow and i did easily and my friends Today, i am the happiest man on Earth, All Thanks to Dr Aziba for saving my marriage and making me a real man today.i asked him about some popular diseases like HERPES,HIV AIDS,HEPATITIS, DIABETICS, CANCERS, WART, Get Ex back ,etc....... which are affecting most people he said there is no disease without a cure , he has it all...You can as well reach the Dr below for help on your problem, for he has the solution to all...
    Email:[ PRIESTAZIBASOLUTIONCENTER@GMAIL COM ]
    WhatsAPP DR [ +2348100368288 ]






    HOW DR AZIBA HELPED ME ENLARGE MY PENIS SIZE FROM 3.5 INCHES TO 11INCHES LONG AND 8.0 GROWTH
    I got married 2 years ago and it just seemed that there was no excitement in my sex life. My dysfunction to perform to the best of my abilities in bed made it harder for my wife and me to have a good time during sex. And i was having the feelings that she may decide to get a divorce one day. I knew something had to be done in order to improve my sex life and to save my marriage because my marriage was already falling apart, so when i was on my Facebook page i came across a story of how Dr Aziba helped him enlarged his penis to 8ins better.so i Immediately copied the Email address of the Dr and explained to him my problem,he gave me some simply instruction which i must follow and i did easily and my friends Today, i am the happiest man on Earth, All Thanks to Dr Aziba for saving my marriage and making me a real man today.i asked him about some popular diseases like HERPES,HIV AIDS,HEPATITIS, DIABETICS, CANCERS, WART, Get Ex back ,etc....... which are affecting most people he said there is no disease without a cure , he has it all...You can as well reach the Dr below for help on your problem, for he has the solution to all...
    Email:[ PRIESTAZIBASOLUTIONCENTER@GMAIL COM ]
    WhatsAPP DR [ +2348100368288 ]

    ReplyDelete
  5. In 2016, I was diagnosed of genital herpes.. I was 31 years old and I had no idea what that was. When my doctor explained to me what Genital Herpes was all about and what type I had...I was freaked out! if I had missed coming to the ER any sooner, I would have possibly died without having the slightest clue of what led to my death, as i have never heard of, or experienced the virus before! The rashes grew and i have been living with it ever since then. Most of the time, I feel dirty knowing i was living with herpes. Though the doctor already encouraged me to keep using my medications even though there is no permanent cure for the virus. So i continued with my medications, which only makes the rashes to disappear, and reappear after some days. Late last year, I started surfing the web, seeking for herbal treatment as alternative. So i was on YouTube one evening,i stumbled upon a comment about Dr. CHUKWU MADU HERBAL HOME and how his herbal medications cured a woman's son of Herpes and I decided to reach out to him. He asked me some questions which i answered, after which He prepared some herbs and sent them to me. He then guided me on how to use them. i used the herbal medications for about ,21days. The rashes gradually dried up. So i went for a test and came back home Herpes free. So My experience with this virus made me to realize, people should find out more about themselves before it's too late. So that when tested positive, they will quickly start making use of the right medication becacause i believe when the right medication is applied, then the sickness is conquered! If you are having any sickness or virus and needs deliverance contact DR.CHUKWU MADU HERBAL HOME. (for your permanent healing) He is the right person to tell your health challenges to. You can contact the doctor via his email address :[ dr.chukwumaduherbalhome@gmail.com ]. Reach him via WhatsApp +2347030936239. Doc. CHUKWU MADU , your saved my life.

    ReplyDelete
  6. WHAT A GREAT MIRACLE THAT I HAVE EVER SEE IN MY LIFE. My names are Clara David I’m a citizen of USA, My younger sister was sicking of
    breast cancer and her name is Sandra David I and my family have taking her
    to all kind of hospital in USA still yet no good result. I decided to go to
    the internet and search for cancer cure so that was how I find a lady
    called peter Lizzy she was testifies to the world about the goodness of a
    herbal man who has the roots and herbs to cure all kind of disease and the
    herbal man email was there. So I decided to contact the herbal man @herbalist_sakura for my younger sister help to cure her breast cancer. I contacted him and told him
    my problem he told me that I should not worry that my sister cancer will be
    cure, he told me that there is a medicine that he is going to give me that
    I will cook it and give it to my sister to drink for one week, so I ask how
    can I receive the cure that I am in USA, he told me
    That I will pay for the delivery service. The courier service can
    transport it to me so he told me the amount I will pay, so my dad paid for
    the delivery fee. two days later I receive the cure from the courier
    service so I used it as the herbal man instructed me to, before the week
    complete my sister cancer was healed and it was like a dream to me not
    knowing that it was physical I and my family were very happy about the
    miracle of Doctor so my dad wanted to pay him 5 million us dollars the
    herbal man did not accept the offer from my dad, but I don't know why he
    didn't accept the offer, he only say that I should tell the world about him
    and his miracle he perform so am now here to tell the world about him if
    you or your relative is having any kind of disease that you can't get from
    the hospital please contact dr.sakuraspellalter@gmail.com or whats app him
    +2348110114739  you can follow him up on Instagram @herbalist_sakura for the cure, he will help you out with the
    problem. And if you need more information about the doctor you can mail me
    davidclara223@gmail.com 

    ReplyDelete
  7. Are you in need of Urgent Loan Here no collateral required all problem regarding Loan is solve between a short period of time with a low interest rate of 2% and duration more than 20 years what are you waiting for apply now and solve your problem or start a business with Loan paying of various bills I think you have come to the right place just contact us We Are Here To Show You A Better Way To Financial Freedom !!!
    Contact Us At : abdullahibrahimlender@gmail.com
    whatspp Number +918929490461
    Mr Abdullah Ibrahim

    ReplyDelete
  8. I was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
    liver already present. I started on antiviral medications which
    reduced the viral load initially. After a couple of years the virus
    became resistant. I started on HEPATITIS B Herbal treatment from
    ULTIMATE LIFE CLINIC (www.ultimatelifeclinic.com) in March, 2020. Their
    treatment totally reversed the virus. I did another blood test after
    the 6 months long treatment and tested negative to the virus. Amazing
    treatment! This treatment is a breakthrough for all HBV carriers.

    ReplyDelete