|Theodore DeWeese and Alan Partin listen to |
presentations during the Research Updates.
In total, over 100 researchers and enthusiasts attended the lively and interactive meeting. Among the guests were giants in the field of prostatic disease including Patrick C. Walsh, Alan W. Partin (Chairman and Urologist-in-Chief of the Brady), Donald S. Coffey, William Nelson (Director of the Sidney Kimmel Cancer Center at Johns Hopkins), Theodore DeWeese (Chairman of Radiation Oncology and Molecular Radiation Science), and Eric Klein (Chairman of the Glickman Urological and Kidney Institute at Cleveland Clinic), and many others.
|Farsana Faisal, a medical student dedicating a year to|
urology research, presents her work at the poster session.
Over 50 posters and presentations were dedicated to improving our understanding and treatment of prostate cancer and benign prostatic diseases.
Highlights from the day and Best Poster Presentations are detailed below.
Patrick C. Walsh Prostate Cancer Research Fund Progress Reports
Targeting the Angiogenic Switch in Prostate - Hans-Joerg Hammers, M.D., Ph.D.Dr. Hammers presented an exciting update on his work of blood vessel growth in prostate cancer. The formation of new blood vessels is critical for prostate cancer progression and its ability to spread to the bones. Importantly, the most commonly found protein in the bones, collagen, is intimately linked to the switch that allows new blood vessels to grow. This work has important implications for preventing the progression prostate cancer in the prostate and the treatment of prostate cancer that has spread to the bones.
Phase I Trial of HSP90 Inhibition and Radiation Androgen deprivation Therapy for High-Risk Localized and Locally Advanced Prostate Cancer - Phuoc Tran, M.D., Ph.D.
Epigenomic Effects of Chronic Inflammation in Prostate Cancer Initiation and Progression - V. Yegnasubramanian, M.D., Ph.D.In a collaborative research project, a team of researchers, led by Drs. De Marzo, Bieberich, and Yegnasubramanian, are investigating the link between inflammation, molecular alterations to prostate cells, and prostate cancer. They are harnessing the power of cutting edge genetic models, genome-wide measurements, and molecular pathology to understand the mechanistic connections between inflammation, epigenetics, and prostate pathologies including cancer. This research could have major implications for prostate cancer prevention and interception.
Production and Evaluation of a PSA-Activated Human Serum Albumin/Proaerolysin Recombinant Protein as Novel Therapy for Metastatic Prostate Cancer -John Isaacs, Ph.D.
Structural and Biophysical Characterization of Gene Silencing by MBD2 Prostate Cancer - Daniel Leahy, Ph.D.Dan Leahy spoke about a collaborative project between the Leahy, Nelson, and Yegnasubramian labs to investigate the molecular nature of interactions between MBD2 and methylated DNA and to identify and characterize inhibitors of this interaction. MBD2 binds to methylated DNA and inhibits expression of nearby genes, including in many cases tumor suppressor genes in cancers. The goal of this work is to identify small molecules that will de-repress tumor suppressors and inhibit growth in cancer cells.
Novel Models of Prostatic Infection and Chronic Inflammation Using Human Prostate Cancer Derived Bacterial Isolates - Karen Sfanos, Ph.D.Dr. Sfanos presented progress on a research project involving mouse models of prostate infections. These models are being used to study the potential contribution of pathogenic microorganisms to the development of chronic inflammation in the prostate. This chronic inflammation may in turn serves to initiate and/or promote prostate cancer development. Notable findings to date include evidence that a single bacterial infection can induce long-term chronic inflammation in the mouse prostate that appears to be dependent on the type of infecting microorganism.
Evaluation of the Long Non-Coding RNAs, PRAC, PRAC2 and Other Non-Coding Elements as Contributors To HOXB13-Induced Prostate Carcinogenesis - William B. Isaacs, Ph.D.
Update - Epidemiology of Prostate Cancer and Benign Prostatic Hyperplasia - Elizabeth A. Platz, Sc.D., MPH
2014 Prostate Research Day Poster Awards
1st Place Awards (Judge Arthur Burnett Award)Androgen deprivation followed by acute androgen stimulation selectively sensitizes AR-positive prostate cancer cells to ionizing radiation
Mohammad Hedayati, Michael C. Haffner, Raju R. Raval, Yonggang Zhang, Haoming Zhou, Emma J. Knight, Susan Dalrymple, John T. Isaacs, Aileen Santos, Russell Hales, William G. Nelson, Srinivasan Yegnasubramanian, Theodore L. DeWeese.
Novel interference of androgen receptor and Pol I in prostate cancer by non-competitive inhibition in vitro and in vivo
Paul Sirajuddin, Michael Moubarek, Jhanvi Patel, Zhiming Yang, Laureen Colis, Karita Peltonen, Hester Liu, Angelo De Marzo, Charles Bieberich, Marikki Laiho,
Honorable Distinction, 2nd Place AwardA transgenic mouse model for inducible inflammation in the prostate.
Arya Ashok, Rebecca A. Walter, Varsha Rao, Laura N. Mutton, Michael Haffner, Angela Alme, Charles G. Drake, Srinivasan Yegnasubramanian, Angelo De Marzo, Charles J. Bieberich
Honorable Distinction, 3rd Place AwardMesenchymal stem cells (MSC) as cell-based vectors for PSA-activated Proaerolysin to sites of prostate cancer
W. Nathaniel Brennen, Oren Levy, Sudhir Ranganath, Michael Schweizer, David Marc Rosen, Sandrine Billet, Neil Bhowmick, Samuel Denmeade, Jeffrey Karp, John Isaacs.
Honorable Mention AwardsFunctional screening identifies microRNAs which alter prostate cancer sensitivity to radiation therapy
Koji Hatano, Binod Kumar, Brian Mears, Wasim Chowdhury, Ronald Rodriguez, Mohammad Hedayati, Yonggang Zhang, Theodore L. DeWeese, Shawn Lupold.
Germline variants in the ASPORIN aspartic acid repeat domain and adverse prostate cancer outcomes
Paula Hurley, Debasish Sundi, Brian Simons, Robert Hughes, Guifang Yan, Marta Gielzak, David Berman, Sarah Isaacs, William Isaacs, Luigi Marchionni, Ashley Ross, Edward Schaeffer
PTEN loss predicts upgrading of prostate cancer from biopsy to radical prostatectomy
Tamara L. Lotan, Filipe L. Carvalho, Sarah B. Peskoe, Jessica L. Hicks, Jennifer Good, Helen Fedor, Elizabeth Humphreys, Misop Han, Elizabeth A. Platz, Jeremy A. Squire, Angelo M. DeMarzo, David M. Berman.
Mechanobiology and tumor growth: Multiphysics modeling, 3D cell culture
Cyclin-dependent kinase 5(CDK5) controls prostate cancer metastasis in vivo and alters tumor immune response
Reclassification rates are higher among african american men than white men on active surveillance
D. Sundi, O. Kryvenko, J. Epstein, B.J. Trock, P.K. Landis, Z. Feng, A.E. Ross, H.B. Carter, E.M. Schaeffer