McGuire EJ, Woodside JR, Borden TA, Weiss RM. Prognostic value of urodynamic testing in myelodysplastic patients. The Journal of Urology. 1981 Aug;126(2):205-9.
In this paper, Dr. McGuire and colleagues evaluated 42 myelodysplastic patients with urodynamics over an average of 7 years. They carefully defined the urodynamic characteristics of these patients:
- 86% had an open bladder neck and non-functional proximal urethra
- Only 9% had coordinated micturation while 83% had areflexic detrusor activity
- 71% had poor compliance (increased bladder pressure with increasing volume)
Take Home: This manuscript is a landmark paper as it defined deleterious effects of high detrusor leak point pressures on the upper urinary tracts and defined the cutpoint at 40cm H20, widely used by urologists around the world for patients with a variety of urological issues.
Classic Manuscripts in Urology will be posted on this blog on regular basis. These articles are meant to highlight the achievements of our predecessors, recognize the work from which we build our careers and stimulate new conversations and discussion on a variety of urological topics. Please feel free to comment on this manuscript, help point out its strengths and weaknesses, or suggest a new manuscript and topic.