The anti-inflammatory properties of MSC can promote regeneration of damaged tissues.  MSC have been used in a variety of experimental settings including the treatment of heart failure, inflammatory bowel disease, cirrhosis, diabetes, chronic obstructive pulmonary disease (COPD) and to prevent rejection after organ transplantation. [2-4] Greater than 1,000 patients around the world have received MSC to treat a variety of conditions.
|MSC track to prostate cancer cells in mice. |
One of the biggest side effects of treatment for prostate cancer is erectile dysfunction (ED). For some men who undergo surgery (radical prostatectomy) to treat their prostate cancer, ED can be particularly difficult to treat. It is know that MSC will hone to areas of prostate cancer. It is believed that this natural ability of MSC may be able to be used to treat post-radical prostatectomy erectile dysfunction in men who have undergone this surgery for prostate cancer. It is postulated that MSC can reduce post-surgery inflammation and reduce nerve damage due to the surgery. In fact, studies in rats have demonstrated improvements in erectile function after MSC injections.
Mesenchymal Stem Cells may reduce post-surgery inflammation and reduce nerve damage due to radical prostatectomy.
|Trinity J. Bivalacqua, MD, PhD|
This is an early-stage study and only a limited number of patients will be enrolled. If you or someone you know was recently diagnosed with prostate cancer please contact the Urology Clinic at Johns Hopkins (410-955-6100) for more information.
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